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KMID : 1145520180040020051
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Journal of Radiopharmaceuticals and Molecular Probes
2018 Volume.4 No. 2 p.51 ~ p.56
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Aliphatic radiofluorination using TBAHCO3 eluate in hydrous organic medium
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Kwon Young-Do
Son Jeong-Min
Chun Joong-Hyun
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Abstract
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Azeotropic drying process is routinely applied to enhance nucleophilicity of [18F]fluoride ion during the nucleophilic production of PET radiotracers; however, the drying process requires usually 15?25 min. Due to the high demand of employing fluorine-18 (t1/2 = 109.8 min) in PET radiopharmaceutical production, several research groups have focused on the method development, obviating tedious removal process of the residual target water ([18O]H2O) for [18F]fluoride ion complex to be used in radiofluorination. Some development in radiofluorination in a mixed organic solvent system was demonstrated with various aliphatic substrates, but only kryptand as a phase transfer agent was utilized in the reported method. Here, we extend to investigate the development scope of applicability with basic alkyl ammonium salt as a phase transfer agent through the extensive elution efficiency study and radiofluorination outcome for aliphatic radiofluorination
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KEYWORD
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Fluorine-18, Radiofluorination, Phase transfer agent, Radiotracer, PET
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